This national population-based cohort study used data from the Hospital Episode Statistics database in England collected between 1997 and 2012. A total of 8794 obese patients who underwent gastric bypass, gastric banding, or sleeve gastrectomy were matched with 8794 obese individuals who did not have surgery.
Patients who underwent surgery had a 77% decreased risk of developing hormone-related cancer (breast, endometrial or prostate cancer) when compared with patients who did not have surgery.
Gastric bypass resulted in the largest risk reduction (84%) for hormone-related cancer but was associated with a greater than twofold increased risk of colorectal cancer.
Additional studies are needed to understand the biological mechanisms behind these findings.
Full bibliographic information
Mackenzie, H. , Markar, S. R., Askari, A. , Faiz, O. , Hull, M. , Purkayastha, S. , Møller, H. and Lagergren, J. (2018), Obesity surgery and risk of cancer. British Journal of Surgery.