This website is intended for Medical Professionals only. By using this site you confirm that you are a healthcare professional.

News
Anti-Inflammatory Diet Linked to Reduced ... Adhering to an anti-inflammatory diet was associated with lower ... (17 Sep 2018)
Salsa dancers ‘less likely to get injured ... Salsa dancers are less likely to get injured while dancing than ... (17 Sep 2018)
Paracetamol use in infancy is linked to ...   Children who take paracetamol during their first two years ... (17 Sep 2018)
Diagnosing and treating resistant ... Resistant hypertension affects 12 to 15 percent of patients ... (11 Sep 2018)
Commonly used antidepressant drugs ... The difficulties that people have in discontinuing ... (13 Sep 2018)
Sunday, 08 April 2018 17:52

Benzodiazepines can help depression Featured

Rate this item
(0 votes)

A paper published in the current issue of Psychotherapy and Psychosomatics, as a result of the collaboration of several universities (University of Bologna, The Pennsylvania State University, Wayne State University, University of Pennsylvania) points to the important role that benzodiazepines may have in depression.

The aim of the study was to perform a systematic review and, when feasible, a meta-analysis of randomized controlled trials using benzodiazepines as a monotherapy versus placebo, antidepressant drugs, or both, in the treatment of adult patients with a primary diagnosis of depressive disorder or anxious depression.

A total of 38 studies met the criteria for inclusion in this study. Only 1 study concerned a newer antidepressant: fluvoxamine. For the meta-analysis, data on response rate included 22 randomized controlled trials, considering benzodiazepines versus placebo (8 comparisons) and benzodiazepines versus tricyclic antidepressants (TCA) (20 comparisons). Results showed a lack of significant differences as to response rate between benzodiazepines and placebo, as well as between benzodiazepines and tricyclic antidepressants. Analysis of individual studies disclosed that, in more than half of the studies comparing benzodiazepines to tricyclic antidepressants and/or placebo, benzodiazepines were significantly more effective than placebo and as effective as tricyclic antidepressants.

These findings highlight that benzodiazepines are a therapeutic option in anxious depression and there are no indications that antidepressant drugs are preferable. There is a pressing need for randomized controlled trials of adequate methodological quality and follow-up comparing benzodiazepines to second-generation antidepressants and placebo in anxious depression. Giovanni Fava, MD, the lead investigator of the study commented: “The data clearly indicate that benzodiazepines have a role in managing anxious and mild depression and present many advantages over antidepressants. The commercial war against benzodiazepines (due to their low cost) has inflated their dependence potential. Antidepressant drugs may be much worse.”


Full bibliographic information:
Benzodiazepines as a Monotherapy in Depressive Disorders: A Systematic Review. Psychother Psychosom 2018;87:65–74

Read 502 times Last modified on Sunday, 08 April 2018 18:57

TheSynapse Videos

0
0
0
0
0
0

Latest news

Highlights

  • WASP Course in Bahrain

    WASP Course, led by Prof Victor Grech and Prof Charles Savona Ventura, has recently organised a course in Bahrain. Co-hosted with Arabian Gulf University, the course, on how to write a scientific paper, focused on quantitative analysis methods and was targeted for medical doctors and allied health professionals.

    Written on April 24, 2018 Read more...
  • Les Laboratoires Servier - Job Vacancy
    Written on June 29, 2018 Read more...

Join

Connect with other Medical Professionals on fb in a closed facebook group

captcha  

Login

Template Settings

Theme Colors

Cyan Red Green Oranges Teal

Layout

Wide Boxed Framed Rounded
Patterns for Layour: Boxed, Framed, Rounded
Top
We use cookies to improve our website. By continuing to use this website, you are giving consent to cookies being used. More details…