This website is intended for Medical Professionals only. By using this site you confirm that you are a healthcare professional.

News
Prolonged paracetamol use during pregnancy ... A study from the Hebrew University of Jerusalem sheds new light ... (25 Apr 2018)
Study Challenges Previous Findings that ... New research does not support the previously observed negative ... (25 Apr 2018)
Early treatment for leg ulcers gets patients ... Treating leg ulcers within two weeks by closing faulty veins ... (25 Apr 2018)
A fat belly is bad for your heart   Doctors should measure central obesity to assess cardiovascular ... (21 Apr 2018)
Can early counselling prevent post traumatic ... A randomized controlled trial published in the current issue of ... (21 Apr 2018)
Wednesday, 18 October 2017 06:47

The cardiovascular risk of antidepressant drugs: New data. Featured

Rate this item
(0 votes)

In the current issue of Psychotherapy and Psychosomatics a meta-analysis is performed on the cardiovascular risk of antidepressant drugs.Antidepressants are commonly prescribed medications, but their long-term health effects are debated. Antidepressants disrupt multiple adaptive processes regulated by evolutionarily ancient biochemicals, potentially increasing mortality. However, many antidepressants also have anticlotting properties that can be efficacious in treating cardiovascular disease.


Authors conducted a meta-analysis assessing the effects of antidepressants on all-cause mortality and cardiovascular events in general-population and cardiovascular-patient samples. Two reviewers independently assessed articles from PubMed, EMBASE, and Google Scholar for antidepressant-related mortality controlling for depression and other comorbidities. From these articles, information was extracted about cardiovascular events, cardiovascular risk status, and antidepressants class. Authors conducted mixed-effect meta-analyses testing sample type and antidepressants class as moderators of all-cause mortality and new cardiovascular events. Seventeen studies met the search criteria.


Results showed that in the general-population, antidepressants use increased the risks of mortality and new cardiovascular events. In cardiovascular patients, antidepressants use did not significantly affect risks. Antidepressants class also moderated mortality, but the serotonin reuptake inhibitors were not significantly different from tricyclic antidepressants. Only “other antidepressants” were differentiable from tricyclic antidepressants. Mortality risk estimates increased when we analyzed the subset of studies controlling for premedication depression, suggesting the absence of confounding by indication.

Authors concluded that the results support the hypothesis that antidepressants are harmful in the general population but less harmful in cardiovascular patients.


 


Source: Journal of Psychotherapy and Psychosomatics

Full bibliographic information:
The Mortality and Myocardial Effects of Antidepressants Are Moderated by Preexisting Cardiovascular Disease: A Meta-Analysis. Psychother Psychosom 2017;86:268-28

 

Read 954 times Last modified on Wednesday, 18 October 2017 08:09

TheSynapse Videos

0
0
0
0
0
0

Latest news

Highlights

  • WASP Course in Bahrain

    WASP Course, led by Prof Victor Grech and Prof Charles Savona Ventura, has recently organised a course in Bahrain. Co-hosted with Arabian Gulf University, the course, on how to write a scientific paper, focused on quantitative analysis methods and was targeted for medical doctors and allied health professionals.

    Written on April 24, 2018 Read more...

SPONSOR MESSAGE

February 27, 2017
0
February 27, 2017
0

Join

Connect with other Medical Professionals on fb in a closed facebook group

Login

Template Settings

Theme Colors

Cyan Red Green Oranges Teal

Layout

Wide Boxed Framed Rounded
Patterns for Layour: Boxed, Framed, Rounded
Top
We use cookies to improve our website. By continuing to use this website, you are giving consent to cookies being used. More details…