This website is intended for Medical Professionals only. By using this site you confirm that you are a healthcare professional.

News
Has aspirin an indication in grief? An investigation that has appeared in the current issue of ... (21 Apr 2018)
Can fish oil supplementation attenuate ... A study published in the current issue of Psychotherapy and ... (21 Apr 2018)
Clinical Evaluation of a Patient with ... In the current issue of Cardiovascular Innovations and ... (21 Apr 2018)
  How to encourage young people to eat ... Nathalie De Cock, a researcher at the University of Ghent, has ... (18 Apr 2018)
Kids hit hard by junk food advertising: new ... Junk food ads are shown more frequently on TV at times when many ... (18 Apr 2018)
Wednesday, 31 August 2016 00:00

Update of H1N1influenza virus

Written by
Rate this item
(0 votes)

by Tanya Melillo Fenech

 

Discovery of a virus variant during the 2009-2010 H1N1 influenza pandemic.  

 

Though the 2009 H1N1 influenza pandemic caused thousands of deaths worldwide, the majority of cases were relatively mild.

 

However studies done by the Imperial College of London, the University of Marburg, the Italian national influenza centre and the Norwegian national influenza centre have resulted in the discovery of a variant of the virus during the 2009-2010 pandemic that carried a mutation termed D222G in a protein ( basically there was a substitution of an amino acid at position 222 of the Haemagglutinin molecule with aspartic acid being replaced by glycine) on the surface of the virus, and people infected with this variant were more likely to have severe and fatal illness.

 

According to the WHO, the overall prevalence of the D222G mutation is recorded as less than 1.8% of total cases of pandemic influenza A(H1N1) cases, compared with 7.1% of the fatal cases.

 

Evidence is showing that the mutant virus could have impaired the lungs’ ability to clear out germs since it has an increasing capacity to infect ciliated cells resulting in the cilia stopping from moving. Thus the impaired clearance function allowed bacteria and viruses to reach the lungs more easily potentially being able to cause pneumonia, making this mutant virus more virulent.

 

New swine flu strain emerges this winter

 

The pandemic H1N1 influenza virus is currently the predominant influenza virus circulating the southern hemisphere this winter.

 

Since its emergence in March 2009, the pandemic influenza H1N1 has remained closely related to the first virus detected in California  in April 2009 called  A/California/7/2001, with little changes in the viruses’ genetic makeup with respect to the glycoprotein  haemagglutinin (HA) and neuraminidase (NA) which are present on the surface.

 

Though some genetic variation was reported – the D222G HA mutation; no clear variant has predominated in any country or region. However a recent report in Eurosurveillance this October is showing that a variant has been detected in this winter seasonal influenza for H1N1, first in Singapore which has then spread to Australia and New Zealand. This new influenza A(H1N1) strain discovered during the current influenza season in the southern hemisphere is called A/Singapore/CC01/2010.

Presently it does not represent a significant antigenic change of the virus but it needs to be monitored further as it may be the start of a more antigenic drift of the pandemic influenza A (H1N1) since several genetic distinct changes have occurred and Winter is now starting in the Northern hemisphere. More studies need to be done to see if this strain is likely to cause more deaths and whether the current vaccine can protect against it completely.

Additional Info

  • TheSynapse Magazines: 2010
Read 2209 times Last modified on Wednesday, 16 November 2016 21:39

TheSynapse Videos

0
0
0
0
0
0

Highlights

SPONSOR MESSAGE

February 27, 2017
0
February 27, 2017
0

Join

Connect with other Medical Professionals on fb in a closed facebook group

Login

Template Settings

Theme Colors

Cyan Red Green Oranges Teal

Layout

Wide Boxed Framed Rounded
Patterns for Layour: Boxed, Framed, Rounded
Top
We use cookies to improve our website. By continuing to use this website, you are giving consent to cookies being used. More details…