This website is intended for Medical Professionals only. By using this site you confirm that you are a healthcare professional.

News
Fast food makes the immune system more ... The immune system reacts similarly to a high fat and high ... (17 Jan 2018)
Cycling does not damage men’s sexual or ... New study in The Journal of Urology® finds that cardiovascular ... (17 Jan 2018)
Estrogen-mimicking compounds in foods may ... New TSRI study suggests breast cancer patients taking ... (17 Jan 2018)
Prolonged periods of sedentary time strongly ... A team of researchers from the NIHR Leicester Biomedical ... (16 Jan 2018)
A more complete Mediterranean diet may ... New study in The Journal of Urology® finds that a high intake of ... (17 Jan 2018)
Wednesday, 31 August 2016 00:00

Update of H1N1influenza virus

Written by
Rate this item
(0 votes)

by Tanya Melillo Fenech

 

Discovery of a virus variant during the 2009-2010 H1N1 influenza pandemic.  

 

Though the 2009 H1N1 influenza pandemic caused thousands of deaths worldwide, the majority of cases were relatively mild.

 

However studies done by the Imperial College of London, the University of Marburg, the Italian national influenza centre and the Norwegian national influenza centre have resulted in the discovery of a variant of the virus during the 2009-2010 pandemic that carried a mutation termed D222G in a protein ( basically there was a substitution of an amino acid at position 222 of the Haemagglutinin molecule with aspartic acid being replaced by glycine) on the surface of the virus, and people infected with this variant were more likely to have severe and fatal illness.

 

According to the WHO, the overall prevalence of the D222G mutation is recorded as less than 1.8% of total cases of pandemic influenza A(H1N1) cases, compared with 7.1% of the fatal cases.

 

Evidence is showing that the mutant virus could have impaired the lungs’ ability to clear out germs since it has an increasing capacity to infect ciliated cells resulting in the cilia stopping from moving. Thus the impaired clearance function allowed bacteria and viruses to reach the lungs more easily potentially being able to cause pneumonia, making this mutant virus more virulent.

 

New swine flu strain emerges this winter

 

The pandemic H1N1 influenza virus is currently the predominant influenza virus circulating the southern hemisphere this winter.

 

Since its emergence in March 2009, the pandemic influenza H1N1 has remained closely related to the first virus detected in California  in April 2009 called  A/California/7/2001, with little changes in the viruses’ genetic makeup with respect to the glycoprotein  haemagglutinin (HA) and neuraminidase (NA) which are present on the surface.

 

Though some genetic variation was reported – the D222G HA mutation; no clear variant has predominated in any country or region. However a recent report in Eurosurveillance this October is showing that a variant has been detected in this winter seasonal influenza for H1N1, first in Singapore which has then spread to Australia and New Zealand. This new influenza A(H1N1) strain discovered during the current influenza season in the southern hemisphere is called A/Singapore/CC01/2010.

Presently it does not represent a significant antigenic change of the virus but it needs to be monitored further as it may be the start of a more antigenic drift of the pandemic influenza A (H1N1) since several genetic distinct changes have occurred and Winter is now starting in the Northern hemisphere. More studies need to be done to see if this strain is likely to cause more deaths and whether the current vaccine can protect against it completely.

Additional Info

  • TheSynapse Magazines: 2010
Read 1591 times Last modified on Wednesday, 16 November 2016 21:39

TheSynapse Videos

0
0
0
0
0
0

Highlights

  • Free Clinic Rooms Available

    Pharmasal, a chain of 6 retail pharmacies has a number of free clinic rooms available within the pharmacies in Tarxien, St. Paul’s Bay, Zejtun, and Dingli. We are looking to increase our list of family doctors and specialists. Family doctors are given preference for the clinic at Zejtun.  For more information, please send an email to This email address is being protected from spambots. You need JavaScript enabled to view it. or call on 99425939.

    Written on October 18, 2017
  • AVAILABLE CLINICS

    Rational Pharmacy, Valley Road, B'Kara requires consultants & family doctors for early morning & afternoon sessions.

    Please contact 99891732 or This email address is being protected from spambots. You need JavaScript enabled to view it. for more information.

    Written on October 09, 2017

SPONSOR MESSAGE

No data displayed on the module. Please check some parameters in the module settings again!

Join

Connect with other Medical Professionals on fb in a closed facebook group

Login

Template Settings

Theme Colors

Cyan Red Green Oranges Teal

Layout

Wide Boxed Framed Rounded
Patterns for Layour: Boxed, Framed, Rounded
Top
We use cookies to improve our website. By continuing to use this website, you are giving consent to cookies being used. More details…